Cinnamaldehyde: the best raw material for new anti-candida drugs

Candidiasis is mainly acute, subacute or chronic infection caused by Candida albicans. It is the most common fungal disease. It often invades the skin and mucous membranes, and can also cause internal organs or systemic infections. The clinical symptoms are intricate and distressed. Children are mostly acute secondary infections. In recent years, with the application of large doses of antibiotics, hormones, and immunosuppressive agents, the incidence rate has gradually increased, and it can endanger life and cause serious consequences. Candida is not very resistant to heat and can heat up to 60°C for 1 hour and die. However, resistance to drying, sunlight, ultraviolet rays, and chemical agents is strong.

Nowadays, amphotericin B has significant toxicity in antifungal drugs, so it is mainly used for diagnosing established deep fungal infections and is in critical condition with progressive development. There are no obvious signs of clinical fungal infections, only patients with positive skin or serum test Should not be selected; the other two main anti-Candida fungi 5-fluorocytosine and fluconazole have obvious side effects, are all hepatotoxic, 5-fluorocytosine has a teratogenic effect, and the drug resistance of the two drug bacteria is becoming increasingly serious, so that clinical The treatment of Candida infections faces great challenges.

Recently, a number of well-known hospitals and large-scale research institutions have verified that cinnamaldehyde has strong antifungal effects, including Aspergillus and Dermatophytes. The antibacterial activity of Candida was particularly obvious. Cinnamaldehyde was found to have strong anti-Candida activity in a bacteriostatic test using a semi-solid drug-based blend of ethanolic extracts of cinnamon. The minimum inhibitory concentration against Candida was determined to be 0.014 mg/L, and the minimum bactericidal concentration was 0.056 mg/L. The antifungal cinnamaldehyde had both stomach and anti-ulcer effects. It was confirmed that cinnamaldehyde is a therapeutic drug for Candida infection.

Clinical practice has confirmed that cinnamaldehyde has excellent medical effects in the treatment of a series of serious diseases such as Candida dermatoses, oral ulcers, gastric ulcers, infertility, and in addition, it has low toxicity and side effects, and is considered by experts to be developed. A new type of effective and safe anti-candida drug.