Application of low temperature cryogenic crushing technology in powder medicament
The drug of the powder depends on the limitations of the raw material manufacturing process. Some drugs can be made into a powder state directly, but most drugs are in bulk, sol or in liquid form. It is necessary to pulverize these drugs to obtain a powder, and the general process employs a normal temperature pulverization method such as shearing, rubbing, tearing, and impact. The powder particle size needs to meet the water solubility requirement, and the powder particle size needs to be reduced to 30 um or less, and a variety of medicines and health care products cannot be pulverized at normal temperature.
We know that during the pulverization process, the material will be heated. What is needed is that we need some unique components of the drug itself. Most of the medicinal components are in a liquid, viscous, soft, and other state. Most of the drug-specific ingredients are denatured after heating and other factors. The temperature generated by the material during the pulverization process generally does not seem to have much influence. We did not pay attention to the temperature of the material at the pulverization point (tearing point). After scientific measurement, it can reach even higher. On the surface, we don’t feel so much. The temperature is because the flow of air reduces the temperature of the material.
Feasibility of cryogenic cryogenic technology:
1. Smashing active cells: At present, we know that cell cryopreservation technology can ensure the activity of cells. It is also desirable to use chilling technology to pulverize drugs. The cryogenic cryogenic pulverization firstly treats the drug at a low temperature for freezing. The liquid nitrogen freezing method is used to freeze the drug we need to pulverize, and the drug is directly cooled to the cell dormant state, and then pulverized by a pulverizer, but it is necessary to avoid the pulverization process. The local high temperature generated in the middle wakes up the active cells.
2, crushing spores, saponins: plants with saponins also undergo molecular recombination during normal temperature pulverization, local high-temperature ginsenosides will be degraded into other substances, and the spores of the fungi will also have the original components of spores. Destroy.
3, protein, vitamins: in all kinds of animals and plants, the original specific protein, vitamins exist in the normal temperature or low temperature state, we generally use the ordinary smash method, but in the smashing process will cause what we need to destroy . By using low-temperature cryogenic technology to smash, the original element content can be guaranteed to be lost. Low-temperature cryogenic pulverization principle: low-temperature cryogenic pulverization The material is directly frozen by heat exchange of liquid nitrogen, and the material that needs to be pulverized is cooled to a state that can be frozen and stored at a rapid and thorough speed.
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