US study found: aspirin or effects of a vaccine

Release date: 2010-01-04

Studies have found that some non-prescription drugs, such as aspirin, hydroxyphenyl acetamide and other drugs that inhibit certain enzymes will affect the effectiveness of the vaccine.
With the arrival of the flu season and the threat of N1H1, the demand for vaccines has been unprecedentedly high. Although those vaccines are effective, researchers at the University of Missouri in the United States have found that some over-the-counter drugs, such as aspirin and hydroxyphenylacetamide, that inhibit certain enzymes, affect the effectiveness of the vaccine.
"If you take aspirin for cardiovascular disease or treat acetaminophen with pain and fever, then you will not get a good antibody response after vaccination," said researcher Charles Brown. "These drugs block the enzyme COX-1 in body tissues. We found that if COX-1 is blocked, the amount of antibodies produced by your body will decrease, and you will need a lot of antibodies to protect it."
COX enzymes play an important role in the regulation of the immune system. The mechanism of action of these enzymes is unclear, and drugs that inhibit them have undesirable side effects. Recent studies have found that drugs that inhibit COX enzyme COX-2 affect the efficacy of vaccines. Brown's research has shown that inhibition of COX-1 enzymes present in whole body tissues such as the brain or kidney can also affect vaccine effectiveness.
Researchers are currently studying the mediation of inflammation and how inflammation causes disease and how to prevent it from happening. Many diseases are inflammatory diseases such as arthritis, cardiovascular disease and diabetes. Unlike what people thought in the past, inflammation is generally a useful body response to help protect our body from infection. Many non-hormonal drugs that treat inflammation reduce the antibody response, which is necessary to fight infection.
"We have been experimenting with animals so far and found that these non-hormonal drugs do inhibit the vaccine. Next we will be studying in humans." Brown said that if the results prove that COX-1 inhibitors can Influencing the effectiveness of the vaccine, do not take aspirin, hydroxyphenylacetamide, ibuprofen and other drugs two weeks before and after the vaccine. Meditech Medical Network

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